Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates
نویسندگان
چکیده
منابع مشابه
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans. While a wild-type TAC1 allele drives high expression of CDR1/2 in response to inducers, we showed previously that TAC1 can be hyperactive by a gain-of-function (GOF) point mutation responsible for constitutive high expressi...
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Within the limited antifungal armamentarium, the azole antifungals are the most frequent class used to treat Candida infections. Azole antifungals such as fluconazole are often preferred treatment for many Candida infections as they are inexpensive, exhibit limited toxicity, and are available for oral administration. There is, however, extensive documentation of intrinsic and developed resistan...
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ژورنال
عنوان ژورنال: Eukaryotic Cell
سال: 2007
ISSN: 1535-9778,1535-9786
DOI: 10.1128/ec.00151-07